A Shot to Save the World: The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine

A Shot to Save the World: The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine

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  • Create Date:2021-12-31 08:51:21
  • Update Date:2025-09-06
  • Status:finish
  • Author:Gregory Zuckerman
  • ISBN:059342039X
  • Environment:PC/Android/iPhone/iPad/Kindle

Summary

Few were ready when a mysterious respiratory illness emerged in Wuhan, China in January 2020。 Politicians, government officials, business leaders, and public-health professionals were unprepared for the most devastating pandemic in a century。 Many of the world’s biggest drug and vaccine makers were slow to react or couldn’t muster an effective response。

It was up to a small group of unlikely and untested scientists and executives to save civilization。 A French businessman dismissed by many as a fabulist。 A Turkish immigrant with little virus experience。 A quirky Midwesterner obsessed with insect cells。 A Boston scientist employing questionable techniques。 A British scientist despised by his peers。 Far from the limelight, each had spent years developing innovative vaccine approaches。 Their work was met with skepticism and scorn。 By 2020, these individuals had little proof of progress。 Yet they and their colleagues wanted to be the ones to stop the virus holding the world hostage。 They scrambled to turn their life’s work into life-saving vaccines in a matter of months, each gunning to make the big breakthrough—and to beat each other for the glory that a vaccine guaranteed。

A #1 New York Times bestselling author and award-winning Wall Street Journal investigative journalist, Zuckerman takes us inside the top-secret laboratories, corporate clashes, and high-stakes government negotiations that led to effective shots。 Deeply reported and endlessly gripping, this is a dazzling, blow-by-blow chronicle of the most consequential scientific breakthrough of our time。 It’s a story of courage, genius, and heroism。 It’s also a tale of heated rivalries, unbridled ambitions, crippling insecurities, and unexpected drama。 A Shot to Save the World is the story of how science saved the world。

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Reviews

Sandeep

Very well written and very readable。 Gregory has done a great job of taking a scientific topic but still producing a page turner。 Of course I am reading it when the 2021 winter has brought the Omicron wave and the report card on the 1st Gen vaccines is being challenged。 However, it is fascinating to read about the journey of the people and companies behind the vaccines and The kind of hard work and perseverance that goes into it。 Can’t help but wonder that for this small lot the pandemic provide Very well written and very readable。 Gregory has done a great job of taking a scientific topic but still producing a page turner。 Of course I am reading it when the 2021 winter has brought the Omicron wave and the report card on the 1st Gen vaccines is being challenged。 However, it is fascinating to read about the journey of the people and companies behind the vaccines and The kind of hard work and perseverance that goes into it。 Can’t help but wonder that for this small lot the pandemic provided an opportunity to convert their work into success, but for so many others there would only be promising work that never got fulfilled。 Gregory weaves in enough personal details of the key people and emotions to tell the story。 While the book flows very well, it does feel that there is more focus on the early days of mRNA research than on how the actual clinical trials for the vaccines played out。 Also the book is US centric but guess that was to be expected。Highly recommended overall。 。。。more

Lynn

Good history of the push to develop vaccines for COVID-19。 It also chronicles the history of mRNA vaccines which most of Big Pharma had no belief in and put little money into research。 It took scientists who were considered outliers and undesirables to pursue the research that finally enabled the Moderna and Pfizer vaccines。 The story also includes J&J and AstroZeneca vaccine development。

Navdeep Pundhir

Avoid at best。 This promises a lot and delivers, well nothing。

Ietrio

The sky is falling and Zuckerman invokes his god to give him wealth and twist the reality according to his whims。

Lisa Marsh

Great read!This will be a history book for future generations! Thrilling tale of how the world came together to believe in the underdog and how perseverance prevailed to save mankind。

Michael Shulman

Absolute Must Read and Possible Pulitzer CandidateAbout as good as non-fiction can be - and a source of hope for treatments and vaccines of other maladies。 A blow by blow look at the development of Covid vaccines going back more than thirty years - much of it by men and women previously unknown to the world at large。 And, to steal a line from the musical Hamilton, when you want to get the job done, give it to an immigrant。 A must read for everyone。

ajay Kumar

a very good read on the covid vaccine and what all companies did to be successful

Maryellen Cyr

An absorbing look at how research and dedicated scientists working for the past 40 years were able to produce successful vaccines for SARS-CoV2。

Tuna Willow

Very engaging and informative read about the history or mRNA vaccines, biotech competition, and the covid-19 vaccine race。

สฤณี อาชวานันทกุล

(ฟังหนังสือเสียงบน audible)ฟังเพลินๆ สนุกดี เล่าประวัติศาสตร์การพัฒนาวัคซีนโควิด-19 ของบริษัทต่างๆ ในอังกฤษและอเมริกาที่เราคุ้นหูกันดี ไม่ว่าจะเป็น Pfizer-BioNTech, Oxford-AstraZeneca, Moderna, Johnson & Johnson และ Novavax โดยเร่ิมต้นไกลมากตั้งแต่ศตวรรษที่ 19 ก่อนจะเร่งเครื่องมาอธิบายจุดกำเนิดของเทคโนโลยีวัคซีนของบริษัทต่างๆ ราว 30-40 ปีที้ผ่านมา จบแล้วจะรู้สึกยกย่องทีมนักวิจัยที่กัดไม่ปล่อย และผู้บริหารที่กล้าเสี่ยง และใครก็ตามที่คิดว่า mRNA เป็นเทคโนโลยี “ใหม่” เลยไม่ไว้ใจ เล่มนี้ก็อธิบายชัดว (ฟังหนังสือเสียงบน audible)ฟังเพลินๆ สนุกดี เล่าประวัติศาสตร์การพัฒนาวัคซีนโควิด-19 ของบริษัทต่างๆ ในอังกฤษและอเมริกาที่เราคุ้นหูกันดี ไม่ว่าจะเป็น Pfizer-BioNTech, Oxford-AstraZeneca, Moderna, Johnson & Johnson และ Novavax โดยเร่ิมต้นไกลมากตั้งแต่ศตวรรษที่ 19 ก่อนจะเร่งเครื่องมาอธิบายจุดกำเนิดของเทคโนโลยีวัคซีนของบริษัทต่างๆ ราว 30-40 ปีที้ผ่านมา จบแล้วจะรู้สึกยกย่องทีมนักวิจัยที่กัดไม่ปล่อย และผู้บริหารที่กล้าเสี่ยง และใครก็ตามที่คิดว่า mRNA เป็นเทคโนโลยี “ใหม่” เลยไม่ไว้ใจ เล่มนี้ก็อธิบายชัดว่ามันผ่านการพัฒนามามากมายขนาดไหนแล้วก่อนจะนำมาใช้ผลิตวัคซีนโควิด-19 และในช่วงโควิด-19 ก็ต้องผ่านด่านอีกขนาดไหนชอบที่ผู้เขียนเน้นอธิบายปูมหลัง ลักษณะนิสัย เกร็ดเล็กเกร็ดน้อย และเหตุการณ์ในชีวิตของตัวละครหลักหลายคนที่พัฒนาวัคซีนแต่ละยี่ห้อ ไม่แพ้การพยายามย่อยหลักการและประเด็นทางการแพทย์ให้เข้าใจง่าย(ขึ้น) รวมถึงการอธิบาย business model ของธุรกิจนี้ ทำให้สนุกไม่แพ้นิยาย ที่ชอบเป็นพิเศษคือเรื่องราวของทีมเบื้องหลัง Moderna กับ Novavax ในเล่ม เพราะผ่านอะไรๆ มาเยอะดี โดยรวมเนื้อหาแน่น เล่าสนุก ผ่านการรวบรวมข้อมูลและบทสัมภาษณ์มากมาย เขียนโดยนักข่าวมือทองของ Wall Street Journal คิดว่าเล่มนี้คู่ควรกับคำโปรย “inside story” และอาจได้เข้าชิงรางวัลพูลิตเซอร์ในอนาคต 。。。more

Jack Reid

Another well-written and well-researched book by Zuckerman。 I've unwittingly read three by now (this one, the man who solved the market, and the frackers)。 Once again, he crafts an excellent narrative around a complicated subject。 In this case, however, I found my eyes often glazed over as he detailed the complexities of medical developments。 He tried to tackle a complex subject - the development of the covid-19 vaccine - and chose a considerable length of time to cover。 Honestly, I thought he'd Another well-written and well-researched book by Zuckerman。 I've unwittingly read three by now (this one, the man who solved the market, and the frackers)。 Once again, he crafts an excellent narrative around a complicated subject。 In this case, however, I found my eyes often glazed over as he detailed the complexities of medical developments。 He tried to tackle a complex subject - the development of the covid-19 vaccine - and chose a considerable length of time to cover。 Honestly, I thought he'd start in late 2019。 Instead, the first 200 pages of the 350-page book cover the 1900s to 2019。 I didn't skip anything or drop the book at any point, which is a testament to his writing。 But I wouldn't have picked up the book if I knew the broad swath of the vaccine landscape he covered。 And how focused he is on the medicine。 。。。more

ElaynaG

Great overview of people and timeline of the top covid-19 vaccines。 Interest was sparked through detailed descriptions of the personalities, not just what they did and how they did it。 Although scientific descriptions of the vaccines were explained, I'd read articles that were more detailed。 This could be a pro/con depending on your expectations。 Great overview of people and timeline of the top covid-19 vaccines。 Interest was sparked through detailed descriptions of the personalities, not just what they did and how they did it。 Although scientific descriptions of the vaccines were explained, I'd read articles that were more detailed。 This could be a pro/con depending on your expectations。 。。。more

Ferhat Culfaz

Nice summary of the history of the companies involved in the COVID 19 vaccines race, and how they got there。 Moderna, BioNTech, J&J, Oxford and Novavax。

Zach

This book seems to be an interesting narration of the events surrounding the pandemic response development。 However, I feel that the author is misleading readers with his title。 I believe very strongly that God has numbered our days and no one can amend that time。 Effectively, no person knows exactly when they are going to die。 Medicine has greatly improved lifespans, but God is still in control and His Will has the ultimate say。 To suggest to one's readers on any topic that something manmade wi This book seems to be an interesting narration of the events surrounding the pandemic response development。 However, I feel that the author is misleading readers with his title。 I believe very strongly that God has numbered our days and no one can amend that time。 Effectively, no person knows exactly when they are going to die。 Medicine has greatly improved lifespans, but God is still in control and His Will has the ultimate say。 To suggest to one's readers on any topic that something manmade will save the world is unintelligent。 Jesus saved this world through His death on the cross and resurrection to defeat sin。 If any person accepts that gift, they are saved and have everlasting life with Him。 To summarize, Jesus is the only thing that will save someone, because the greatest sickness one has comes from their sin。 That cannot be healed by any work of medicine。 The world is looking for a "savior", so this title will naturally catch eyes。 However, they should be made aware that the vaccine that actually saves them is Jesus, and the only work needed is to accept His gift。 。。。more

Richard

All the companies that you now know the name of (Moderna, BioNTech) and the people behind them: pivots, struggles, and then COVID。 We so nearly didn't have these companies around。 All the companies that you now know the name of (Moderna, BioNTech) and the people behind them: pivots, struggles, and then COVID。 We so nearly didn't have these companies around。 。。。more

Wendy

Impeccably researched, a brilliant recounting of the hard work done for decades to come up with vaccines for viruses。Amazing and informative read。

Stefan Mitev

Историята на COVID-19 ваксините в една книга。Най-важното, което трябва да запомните е, че технологията с информационна РНК се разработва над 10 години преди началото на пандемията。 Фирмите BioNTech и Moderna използват иРНК методи за имунотерапия на тумори и разработват други ваксини - срещу грип, HIV, RSV и др。Все още много хора у нас се страхуват от ваксините。 Поне част от тях са недоверчиви, защото смятат, че наличните продукти са създадени "прекалено бързо" и не са достатъчно изпитани。 Фактит Историята на COVID-19 ваксините в една книга。Най-важното, което трябва да запомните е, че технологията с информационна РНК се разработва над 10 години преди началото на пандемията。 Фирмите BioNTech и Moderna използват иРНК методи за имунотерапия на тумори и разработват други ваксини - срещу грип, HIV, RSV и др。Все още много хора у нас се страхуват от ваксините。 Поне част от тях са недоверчиви, защото смятат, че наличните продукти са създадени "прекалено бързо" и не са достатъчно изпитани。 Фактите са съвсем други。 Научният прогрес ни позволява да разполагаме с ваксини, за които в миналото се е чакало с години。 Книгата разбива всички митове на антиваксърите за опасностите от т。нар。 "Биг Фарма"。 Факт е, че много хора днес дължат живота си на компаниите BioNTech, Moderna, AstraZeneca。Прочетете я, ако все още имате някакви съмнения относно ваксинацията。 。。。more

Ray L。

A remarkable job of reporting (in essentially real time) the efforts to create a COVID vaccine that reminds us of the effort and energy and money and skill and serendipity involved in producing the various vaccines we now enjoy。 Zuckerman is able to provide enough background and context and explain the science in ways that are comprehensible without bogging down the narrative。 And to keep the story of how we arrived at this time engaging even though we already know the broad outlines of Moderna; A remarkable job of reporting (in essentially real time) the efforts to create a COVID vaccine that reminds us of the effort and energy and money and skill and serendipity involved in producing the various vaccines we now enjoy。 Zuckerman is able to provide enough background and context and explain the science in ways that are comprehensible without bogging down the narrative。 And to keep the story of how we arrived at this time engaging even though we already know the broad outlines of Moderna; BioNTech/Pfizer, J&J, Oxford/AstraZeneca, and Novavax。 。。。more

Jim Mackell

It's better if you skip the first 200 pages。 Then it gets interesting。 It's better if you skip the first 200 pages。 Then it gets interesting。 。。。more

Bob Eisenberg

I could not put down the story of how scientists created the vaccines that saved us。 Imagine what the USA would be like with six million dead, which is what Covid delta would have done without the vaccines。 Zuckerman tells an entertaining and important story about the intertwined obsessions of molecular biologists struggling with each other and with molecules as they created a new technology。 Let us hope that the public comes to understand that the spectacular improvements in health, like the va I could not put down the story of how scientists created the vaccines that saved us。 Imagine what the USA would be like with six million dead, which is what Covid delta would have done without the vaccines。 Zuckerman tells an entertaining and important story about the intertwined obsessions of molecular biologists struggling with each other and with molecules as they created a new technology。 Let us hope that the public comes to understand that the spectacular improvements in health, like the vaccines that are saving us, come from a social process created and catalyzed by the NIH, much more than anyone else。 Physician scientists, and the Congress, has recognized since 1949 that the important advances almost always come from the scientists obsessed with understanding disease, even more than treating it。 They do not often write the best grants。 But they do the most important work! Let us hope we develop such a community of scientists interested in reflecting sunlight to cool the earth, before we are warmed so much that millions of us drown。 So much carbon dioxide is already in the atmosphere and so much more is on its way as the underdeveloped world cools itself with air conditioning that nothing else will work I fear。 。。。more

Jason Senensky

Good!

Nayab

An insightful read covering not only the major Covid vaccines (moderna, Pfizer/BioNTech, AZ, Janssen and Novavax) and their developments but also the history of the technologies they are based on (starting with developments in the 80s during the HIV pandemic)。 It was interesting to learn more about the quirky personalities and the hard work of so many interesting people involved in these major breakthroughs, including academics, government scientists, people in biotech/Pharma, and investors。 Thi An insightful read covering not only the major Covid vaccines (moderna, Pfizer/BioNTech, AZ, Janssen and Novavax) and their developments but also the history of the technologies they are based on (starting with developments in the 80s during the HIV pandemic)。 It was interesting to learn more about the quirky personalities and the hard work of so many interesting people involved in these major breakthroughs, including academics, government scientists, people in biotech/Pharma, and investors。 This book is a good recap of how development these vaccines was neither easy nor did it come out of thin air; it was built on decades of hard work from hundreds of people - and it is work that’s still ongoing。 。。。more

Brad

Greg did an excellent job researching these stories and I believe it will be without a doubt the definitive book on the vaccine race。 That’s no small thing given what a profound impact this will have on history。 While there is a lot of science in it, the book is written in a way that anyone will be able to enjoy it。 And for those who love science or work in the biotech industry, you will not only enjoy it, you will love it。 I am a biotech investor and consider this required reading for anyone co Greg did an excellent job researching these stories and I believe it will be without a doubt the definitive book on the vaccine race。 That’s no small thing given what a profound impact this will have on history。 While there is a lot of science in it, the book is written in a way that anyone will be able to enjoy it。 And for those who love science or work in the biotech industry, you will not only enjoy it, you will love it。 I am a biotech investor and consider this required reading for anyone coming up in our industry going forward。 There are many elements that make the book a success。1。 An appreciation for the long arc of science。 The vaccine companies made success look easy, but the reality is anything but。 Science doesn’t happen overnight, and this well-researched book talks about the decades of work that added up to today’s covid vaccine technologies (mRNA, adenovirus, protein subunit)。 Scientists will appreciate how the book connects the dots between basic research understandings from decades ago and today’s successes。2。 A fascinating story about interesting people。 Any good story is ultimately about the people, and there are a lot of fascinating heroes in this book。 Those in science will be able to relate to the ups and downs that the scientists in the book experience, and also their dogged determination over decades to their areas of expertise。 The book also does a nice job of giving credit to some of the unsung heroes behind the scenes who made big decisions or discoveries that shaped the direction of the development of these technologies。3。 The book reminds us that history could have gone differently。 It is easy to forget how doubtful it seemed at times that we would even have effective vaccines at this point。 The book reminds us that there were a lot of near misses, and how the vaccine race could have taken bad turns。 For example, it wasn’t until the last minute that Pfizer and BioNTech changed which construct they went with for their phase 3 trial (from a ‘receptor binding domain’ design to a ‘whole of spike protein’ one)。 Where would we be today if they hadn’t made this late change? It is a reminder to be thankful for these miracles。4。 There are major scoops in here。 Even for those who followed the vaccine race closely in real time, there are behind the scenes details you will learn that are real scoops。 For example, in the spring of 2020 while its phase 1 trial was underway at NIAID, Modera’s CEO was worried about having enough money to build out manufacturing and went just about everywhere asking for help, including to Merck。 Yet Merck turned him down。 That’s a big miss by Merck on what would have been a historic partnership。 Also, I was unaware that Pfizer initially recommended to BioNTech that it not pursue a COVID vaccine (though they thankfully changed their mind quicky)。5。 The book teaches important lessons。 While there are many things to be learned from this story, for me the biggest one relates to the breakthrough success of mRNA。 Almost all of the biggest companies and many of the largest and most sophisticated life sciences investors were mRNA skeptics leading up to COVID。 Yet its success is likely to become one of medicine’s most important advances in decades。 As an investor, this has taught me lessons about not following the crowd, giving longshots a chance, and understanding that the biggest and most transformational advances in technology will likely catch the establishment by surprise。 Today I have a greater appreciation for the people who are out there working on the ‘next mRNA’, and how they will likely be doubted too。This is an excellent read that I highly recommend。 Everyone in biotech will love it。 。。。more