A Decodificadora

A Decodificadora

  • Downloads:3301
  • Type:Epub+TxT+PDF+Mobi
  • Create Date:2021-03-23 02:32:34
  • Update Date:2025-09-07
  • Status:finish
  • Author:Walter Isaacson
  • ISBN:6555601825
  • Environment:PC/Android/iPhone/iPad/Kindle

Summary

Biógrafo de Albert Einstein, Steve Jobs e Leonardo da Vinci narra a trajetória de Jennifer Doudna, cientista premiada com o Nobel de Química por suas descobertas sobre edição de DNA

Quando Jennifer Doudna ainda cursava a sexta série, encontrou em sua cama um exemplar de A dupla hélice, de James Watson, deixado por seu pai。 Avançando pelas páginas, Doudna ficou fascinada com os bastidores da competição científica pela descoberta dos tijolinhos que constroem a vida。

Motivada pela paixão de entender o funcionamento da natureza e por transformar descobertas em invenções práticas, Doudna ajudaria a realizar aquilo que o próprio James Watson, um dos descobridores da estrutura do DNA, classificara como o próximo avanço científico mais importante da biologia。 Observando o modo com que há bilhões de anos as bactérias combatem os vírus, ela e seus parceiros de pesquisa descobriram algo capaz de transformar a vida humana: uma ferramenta de manuseio simples capaz de editar a estrutura do DNA。 O CRISPR, como foi batizada, abriu um novo mundo de milagres da medicina e levantou delicadas questões éticas。

Se a última metade do século passado foi uma era digital, baseada no microchip, no computador e na internet, estamos agora no limiar de uma revolução da vida e da ciência: as crianças que estudam programação digital se juntarão às que estudam o código da vida。 O uso do CRISPR e a corrida para o desenvolvimento de vacinas contra a Covid-19 estão acelerando a transição para essa nova era de inovações biológicas。

Devemos usar esses novos poderes para hackear a evolução e nos tornarmos menos suscetíveis a infecções virais? Para prevenir a depressão? Devemos permitir que o poder aquisitivo dê aos pais a chance de modificar características como a altura, a estrutura muscular ou o QI de seus filhos?

Tendo capitaneado as importantes descobertas que levaram ao CRISPR, Doudna assumiu papel de destaque na discussão das questões morais que envolvem a edição do genoma humano e, com sua parceira de pesquisa Emmanuelle Charpentier, ganhou o Prêmio Nobel de Química em 2020。 Sua trajetória é uma emocionante história de detetive que envolve as mais complexas maravilhas da natureza, indo das origens da vida ao futuro da nossa espécie。

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Reviews

Matthew Aujla

I hope that this book is successful and expands the population that is thinking about genetic engineering and its implications for humanity。 However, I was disappointed that this was less of a biography of Doudna and more of an article on the history & recent events related to CRISPR。 Am I the only one who is consistently disappointed with Isaacson's biographies? I highly recommend starting with Doudna's own "A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution" over I hope that this book is successful and expands the population that is thinking about genetic engineering and its implications for humanity。 However, I was disappointed that this was less of a biography of Doudna and more of an article on the history & recent events related to CRISPR。 Am I the only one who is consistently disappointed with Isaacson's biographies? I highly recommend starting with Doudna's own "A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution" over "The Code Breaker" 。。。more

Bryan Gish

I bought this book on March 9th at my local bookstore and have just finished the final sentence and I'm looking forward to reading it again, possibly in audio format next。What a wonderful book。The main story of Doudna and how she became the person she is was a wonderful read。 But this book was much more than just her story and it was a delight to get to "meet" all of the other scientists and doctors who have contributed to this science of CRISPR。 And in addition to people's lives it was very int I bought this book on March 9th at my local bookstore and have just finished the final sentence and I'm looking forward to reading it again, possibly in audio format next。What a wonderful book。The main story of Doudna and how she became the person she is was a wonderful read。 But this book was much more than just her story and it was a delight to get to "meet" all of the other scientists and doctors who have contributed to this science of CRISPR。 And in addition to people's lives it was very intriguing to learn about the science of gene editing, and Isaacson wrote it in such an easy to understand manner。 I'm no scientific mind, but I easily understood the concepts and science。 (At least my feeble brain thinks it did! :-D) A marvelous read。 。。。more

Kathy Taylor

A very interesting and timely book ! The science was explained in a way that made a layperson, like me, able to follow。 It was a blend of themes: the scientists themselves, the science world and how science is practiced, the competitive practices of scientists, the ethical challenges of scientific discoveries。 I highly recommend this book!

Onceinabluemoon

Dnf quit around 30%, kept drifting away, thinking of school days in biology, just wasn’t a topic I could embrace。。。

Brendan Hughes

While long, this is another masterpiece by Walter Isaacson。This book opened me up to a whole new world that I admittedly did not know much about。 I think this will change in time especially due to COVID-19, but this field historically just hasn't received the attention that other areas such as computer technology have received。 Isaacson did a good job taking complex subjects and putting them into a form that can be understood by individuals with minimal knowledge about the medical field。 While long, this is another masterpiece by Walter Isaacson。This book opened me up to a whole new world that I admittedly did not know much about。 I think this will change in time especially due to COVID-19, but this field historically just hasn't received the attention that other areas such as computer technology have received。 Isaacson did a good job taking complex subjects and putting them into a form that can be understood by individuals with minimal knowledge about the medical field。 。。。more

Jennifer Sun

Who designed the cover talk about tacky and cheap looking?It is a pretty informative book,I think the writer did a good job making such a complicated process seem understandable。 But if you are not well educated in biology and chemistry you will have a hard time understanding some of the jargon。

Wisey

Also talks about making vaccines against covid

Mich

While this book focuses much on Jennifer Doudna and her work, it’s a lot more。 The reader is skillfully introduced to the biochemistry and discovery of the roles of DNA/RNA, how scientific advances build on the contributions of others, yet how cutthroat competition affects behavior and discovery。 We learn how the development of CRISPR enzymes to edit genes was accomplished leading to its use to cure diseases such as sickle cell anemia。 Ethical questions are debated about whether diseases should While this book focuses much on Jennifer Doudna and her work, it’s a lot more。 The reader is skillfully introduced to the biochemistry and discovery of the roles of DNA/RNA, how scientific advances build on the contributions of others, yet how cutthroat competition affects behavior and discovery。 We learn how the development of CRISPR enzymes to edit genes was accomplished leading to its use to cure diseases such as sickle cell anemia。 Ethical questions are debated about whether diseases should be eliminated not only in embryos but as a result eliminated in its future generations。 The book somehow covers the current Covid-19 pandemic and how the university labs quickly pitched in to develop antigen tests and how the vaccines were developed。Walter Isaacson interviews all the key players: Doudna, Charpentier (Nobel winners in October 2020), Zheng, Church, Lander, Watson, and scores of others。 Eminently readable and can’t be put down 。。。more

Lucas

This book is basically Walter Isaacson writing about the world of gene editing and writing about himself, while trying to tell himself he’s writing a biography of Jennifer Doudna。 There’s a lot more he could have gone into on Doudna if he actually wanted to write her biography, but he didn’t。 There’s a lot of fascinating questions about gene editing, including the ethical implications and how it should be regulated。 Those questions can probably be explored in more interesting ways by other books This book is basically Walter Isaacson writing about the world of gene editing and writing about himself, while trying to tell himself he’s writing a biography of Jennifer Doudna。 There’s a lot more he could have gone into on Doudna if he actually wanted to write her biography, but he didn’t。 There’s a lot of fascinating questions about gene editing, including the ethical implications and how it should be regulated。 Those questions can probably be explored in more interesting ways by other books though, fiction or nonfiction。 。。。more

And vice versa

A page-turner。 Honest。Not sure anyone else could turn this intensely scientific story into such a dramatic, emotional and compelling narrative the way Isaacson has。 If you’re curious about the almost cutthroat way science is often done today, as well as about the easy-to-use gene editor CRISPR and the future of designer babies and the real-time fight against pandemics, you’ll not want to put this down。 Terrific。

Laura

Really fascinating。 Finished listening to it as I planted rose bushes in my yard。

Marks54

Walter Isaacson has produced another biography of a genius of consequence to the world。 “The Code Breaker” is about Jennifer Doudna, who has pioneered, along with a number of outstanding colleagues and competitors, the science of CRISPR and techniques for editing human genes - as well as recently winning the Nobel Prize for her work (along with Emmanuelle Charpentier)。 The story of Professor Doudna life to date is a terrific story that is well told。 Along with this, Isaacson provides his own eff Walter Isaacson has produced another biography of a genius of consequence to the world。 “The Code Breaker” is about Jennifer Doudna, who has pioneered, along with a number of outstanding colleagues and competitors, the science of CRISPR and techniques for editing human genes - as well as recently winning the Nobel Prize for her work (along with Emmanuelle Charpentier)。 The story of Professor Doudna life to date is a terrific story that is well told。 Along with this, Isaacson provides his own efforts to translating the science of genetics, gene splicing, molecular biology, and other dark realms into terms that more general (and non scientific) readers can appreciate - at least a little。The book is important and hugely relevant to our current situation with COVID-19。 To appreciate this, consider that with the last pandemic of a scale comparable to the current one - the Spanish Flu of 1918-1919 - science did not win the battle。 The flu did its deadly work and moved on。 In fact, we did not know what viruses were at the time and did not identify the virus behind the Spanish Flu definitively until the 1990s。 Compare that to COVID-19, whose genetic signature was fully identified and distributed within the scientific community。 From there, dozen or so vaccines were in the works fairly rapidly, with vaccination well underway in the US and Europe (and hopefully soon elsewhere) within a year。 The leading vaccines have effectiveness scores in the 80-90+% range, depending on where you get your statistics。 This is in comparison to the much lower effectiveness we are used to with the annual flu vaccines。 Effective vaccines produced in record time, at least compared with earlier efforts。 How did that happen? How did they do that? How do the Pfizer and Moderna vaccines work? The science of RNA and the techniques for how to do things and edit genes towards some intended effect are behind this。 Isaacson’s book is about that science and the people whose work initiated the area and moved it along。 He even includes some chapters on COVID-19 towards the end of the book and how typically cutthroat academic research could turn cooperative to fight the virus。Isaacson’s writing is, as usual, magnificent。 He writes well about science。 He also does a good job of writing about genius。 That is trickier, in that by definition genius is not easily recognized or described by those of us who are not geniuses。 It just seems like mystery to many。 At the same time, Isaacson tries to stay clear of hero worship and challenges everyone he interviews regarding the conflicts and murkier issues of the story he is telling。 He does that here to great effect。 Related to this is how different knowledge realms come to interact to produce world changing outcomes。 That is true for different scientific specialties。 It also involves the interactions of science, medicine, law, and government。 This is well covered in the book, especially the interactions of big science with law and government in such matters as intellectual property protections and public health and safety。I could go on, but I would rather people just read the book。 Isaacson’s book on Steve Jobs was a really good book, but it is possible that “The Code Breaker” will prove to be his best and most important yet。 。。。more

Scott Norton

Outstanding!I have only given 5 star reviews 4 or 5 times in my lifetime。 If you enjoyed other books about science and medicine including "Complications", "The Emperor Of All Maladies" and "Bad Blood", you will likely LOVE this fascinating and thoroughly researched book! Outstanding!I have only given 5 star reviews 4 or 5 times in my lifetime。 If you enjoyed other books about science and medicine including "Complications", "The Emperor Of All Maladies" and "Bad Blood", you will likely LOVE this fascinating and thoroughly researched book! 。。。more

Peggy

This book is complicated, so my review will be also。The first part of the book is basically a biography of Jennifer Doudna, focusing on her academic and research career。 In this part, there is an explanation of DNA, RNA and it's various forms, and a plethora of acronyms (for which a term glossary would have been quite helpful, but is not provided in the text。) I have significant laboratory medicine training, so the biochemistry presented here was not a challenge。 Some of the terminology and acro This book is complicated, so my review will be also。The first part of the book is basically a biography of Jennifer Doudna, focusing on her academic and research career。 In this part, there is an explanation of DNA, RNA and it's various forms, and a plethora of acronyms (for which a term glossary would have been quite helpful, but is not provided in the text。) I have significant laboratory medicine training, so the biochemistry presented here was not a challenge。 Some of the terminology and acronyms have changed since my training days, so these required more tracking。 Can a non-science major follow this part? Tougher question。 Would recommend trying though, as the latter part of the book raises significant questions which we all should have a say in answering。The parts of the book on academic politics, academic one-upmanship and patent wars are a part of the story, but less interesting and somewhat distressing personally。The bigger questions come near the end of the book。 This area of scientific endeavor has really opened a Pandora's box。 Gene editing can be done by anyone with internet access and a payment method。 It is not confined to Level 4 biohazard labs。 The idea home brewers can change a bacterium's antibiotic resistance profile is chilling。 Changing viruses? Equally so。 Slippery slopes。 These Isaacson outlines fairly accurately。 Mucking with a human germline genome? Not ready for prime time。 I am amazed that some of the scientists involved are even considering it。 Appalled that it actually happened。 A human genome contains billions of base pairs。 How do we know any edit launched will be specific enough to only hit the intended target? Answer, we don't。 Unintentionally burdening future generations with deleterious, unintended edits, is a real possibility here。 This part of the book is worth the read, and active discussion。As to COVID, interesting to read how various vaccines work。 Nice to see the scientific community come somewhat together in a pandemic, if still protecting the commercial patent aspect。 The speed with which our country was able to lauch effective vaccines would not have been possible without the DNA and RNA research done to date。 There are clear medical treatments available for devastating diseases also related to the study of these and related cellular mechanisms。 There is still hope at the bottom of Pandora's box。 But we need to use a lot of wisdom also。 。。。more

Kathleen Kirchner

Absolutely fascinating。 One of the best of 2021。

Uurtsaikh Baatarsuren

I did not join Goodreads to write this kind of review, but this book is"The best of the best of the best of the best of the best 。。。"╰(*°▽°*)╯ I did not join Goodreads to write this kind of review, but this book is"The best of the best of the best of the best of the best 。。。"╰(*°▽°*)╯ 。。。more

Chaitra

This review has been hidden because it contains spoilers。 To view it, click here。 I loved this book, which is quite surprising, because in certain parts the science is quite dense。 It's not even science of the type I understand - I dropped biology in high school and switched over to computers and logic the minute I could。 I liked chemistry but I preferred the inorganic type, and this is molecular biology spliced with organic chemistry。 It's all highly interesting though, because it makes me hopeful for a horrible future。 Some random thoughts。I wondered if I was that into comi I loved this book, which is quite surprising, because in certain parts the science is quite dense。 It's not even science of the type I understand - I dropped biology in high school and switched over to computers and logic the minute I could。 I liked chemistry but I preferred the inorganic type, and this is molecular biology spliced with organic chemistry。 It's all highly interesting though, because it makes me hopeful for a horrible future。 Some random thoughts。I wondered if I was that into comic books that my first thought was not bye bye inherited diabetes (as it should have been), but X-Men。 I don't mean super strength or speed or whatever。 I mean genes that will let my descendants live in an atmosphere that is increasingly saturated with greenhouse gases。 If gene editing solves it, I'm all for it - it's not like anyone is getting climate change under control any time soon。 And while you're at it, make this same thing happen for the world's trees and corals and animals and fish? If I was confident I wouldn't infect myself with some horrible disease because I did something wrong, I would have bought my Odin kit by now。I'm pleased all of the scientists seem aware of the ethics of their findings。 But I also find it weird that they weigh in about writing out bipolar disease, about writing out schizophrenia because we wouldn't have art or contribution to the world anymore。 It made me upset - it's not a tortured person's responsibility to contribute to the world。 It's the world's responsibility to alleviate their pain if it can。 The world fails them repeatedly。 So until the world can be fixed, table that discussion, I think。 I felt terrible for that kid with the sickle cell anemia who bravely says I don't mind it because it taught me empathy and patience? Kiddo, you shouldn't have to have a horrible disease to learn empathy and patience。 Millions have empathy, millions have patience without also having sickle cell anemia。 Also, if you weren't already going to be empathetic, the disease wouldn't have helped you。 On the whole I liked the pettiness involved between the various teams, because it made for interesting reading。 It also wasn't tragic the way Rosalind Franklin turned out to be。 But I could have done without James Watson。 I know it's not possible to talk about genetics without talking about him, but -- he's quite reprehensible。 I also thought Isaacson lost a good opportunity to needle him on the equalizing possibilities of gene editing in his interview。 I also really liked the author inserts。 I usually don't like this, because it's not giving me a chance to make up my own mind, but he seemed fair。 And also, he came across as a geek who was genuinely interested in all of this fresh science, and that made the book that much more enjoyable。 I also really liked hearing about his covid vaccine trial description。 。。。more

Steve

This is likely the most detailed and exciting book I've ever read about scientists。 I've read a number of Isaacson's books a d this is also the first in which he has been so involved that he constantly inserts himself into it by repeatedly using "I"。The initial reviews I saw on Goodreads, complained about too much scientific detail。 That seems to be over now and perhaps reflective of the group that received preview copies。 A book about scientists should go over some of the science in a clear and This is likely the most detailed and exciting book I've ever read about scientists。 I've read a number of Isaacson's books a d this is also the first in which he has been so involved that he constantly inserts himself into it by repeatedly using "I"。The initial reviews I saw on Goodreads, complained about too much scientific detail。 That seems to be over now and perhaps reflective of the group that received preview copies。 A book about scientists should go over some of the science in a clear and accurate manner。 That is well accomplished here。 From the beginning of Doudna's interest in biology via Watson's "Double Helix" through her fascination with RNA to her work on CRISPR and up to CRISPR applications to current problems including not just the treatment of genetic disorders, but CoVid19 applications, this book covers it all。It is inspirational and Jennifer Doudna is inspirational herself。 This should lead a good number of people to an interest in biomedical and biochemical research。 The cast of characters is broad and international。 The point of that is together we can accomplish much。 The author himself says that the research going into the book has led him from trepidation to optimism on CRISPR。 I feel optimism to science in general。 And In addition to optimism towards medical science, I am optimistic that AI/ML will also contribute and play a role in advances in medical science and science in general。The theme mentioned near the start of the book as expressed by Doudna is “Nature is beautiful。” Researchers that I’ve known at NIH have expressed similar thoughts。 And they’ve also said science news is a good antidote to the news of the rest of the world。 All very true。 。。。more

kris

Amazing, wonderful, engaging - everyone should read this book。 The beginning of the book has quite a bit of science that is fairly simple, but may cause some people to get bogged。 At this point - just keep going。 The science is interesting, but the story doesn't require you to understand all the little details。 The same is true of the names and contribution of every scientist involved - just keep going, you don't have to remember all the names。 The progress made in gene editing and the ethics di Amazing, wonderful, engaging - everyone should read this book。 The beginning of the book has quite a bit of science that is fairly simple, but may cause some people to get bogged。 At this point - just keep going。 The science is interesting, but the story doesn't require you to understand all the little details。 The same is true of the names and contribution of every scientist involved - just keep going, you don't have to remember all the names。 The progress made in gene editing and the ethics discussion is the heart of the story。 I liked hearing about the competition and collaboration, but the ethical dilemma is the important part。 The end of the book is how this work helped and is continuing to help us get out of the coronavirus pandemic。 It's wonderful to read about the direct application of this work to current real-world problems。 This book should be required reading for everyone。 Isaacson is a brilliant writer and makes very complex topics come alive for the most science-resistant reader。 。。。more

Larry Nagel

Absolutely loved this book。 Well written and informative about a subject I know little about。 Most interesting is the competition between the various players。 All are looking for the success of their research but would be a little more happy with their own success in beating their competition to publish。 Isaacson has given us an exciting read and does for microbiology what The Queen’s Gambit did for chess。 Highly recommended。

Mark Donovan

Exceptional! Both the story and the story teller。 I started to well up when she won the nobel prize, even though I knew it was coming。 I loved the photos, especially the one of isaacson wearing a lab coat and goggles doing science。This book differed from his other biographies, because Doudna is still alive, allowing him to do a (better) form of journalism following her around and documenting events at they unfolded。 Made things especially captivating。Loved the part about using crisper cas9 for c Exceptional! Both the story and the story teller。 I started to well up when she won the nobel prize, even though I knew it was coming。 I loved the photos, especially the one of isaacson wearing a lab coat and goggles doing science。This book differed from his other biographies, because Doudna is still alive, allowing him to do a (better) form of journalism following her around and documenting events at they unfolded。 Made things especially captivating。Loved the part about using crisper cas9 for covid vaccines。 Would highly recommend。 。。。more

Barb

3。5 stars

Tom

Thank you to Net Galley for this copy。Every once in a while a book comes along that goes on the top shelf of favorite books ever。 This is one of them。 Walter Isaacson is the best biographer that I have ever read。 How he can take on a topic like MRNA and explain it so well is beyond me。 This is a story that really starts back with Watson and Crick discovering DNA right up to the vaccines for COVID 19。 This story presents the personalities, battles, collaborative and not so collaborative endeavors Thank you to Net Galley for this copy。Every once in a while a book comes along that goes on the top shelf of favorite books ever。 This is one of them。 Walter Isaacson is the best biographer that I have ever read。 How he can take on a topic like MRNA and explain it so well is beyond me。 This is a story that really starts back with Watson and Crick discovering DNA right up to the vaccines for COVID 19。 This story presents the personalities, battles, collaborative and not so collaborative endeavors。 I obviously loved the book and recommend it highly。 。。。more

Darie

This book is incredible, even though the subject is very "scientific" and you’d think would require rather advanced knowledge in biology and chemistry to go through it, it is written in a simple and tangible manner。 It covers short biographies of brilliant minds of our time and it passes on a revelation, the pace genetic engineering moves with today that is incredible。 2021 is a perfect year to read this book, I’d compare this journey to what I would believe I’d experience if I got to read Steve This book is incredible, even though the subject is very "scientific" and you’d think would require rather advanced knowledge in biology and chemistry to go through it, it is written in a simple and tangible manner。 It covers short biographies of brilliant minds of our time and it passes on a revelation, the pace genetic engineering moves with today that is incredible。 2021 is a perfect year to read this book, I’d compare this journey to what I would believe I’d experience if I got to read Steve Job’s biography before the Apple Revolution started。 It is fascinating, curious, suspenseful and you just can’t stop reading。 Page by page I was fascinated how curiosity-based questions are leading to breakthrough findings, and how impactful those became in context of the Covid pandemic。In conclusion, receiving this book as a gift for International Womens’ Day it is deffinately symbolical and trully inspiring to learn about several women that shoock bio-tech world。 This book is certainly another uncompromised win for Isaacson。 。。。more

Alshaijihumood

To you, who was a pioneer in the ride of knowledge and education 。。 To you, who had given and did not wait for anything 。。 To you I give expressions of thanks and appreciation。 To DR JENNIFER DOUDNA

Santi Mestre Fos

My all-time favorite non-fiction book。 Curiosity-driven science is changing the world!

Joyce Schiff

Deals with myriad issues relating to the discovery of cloning genes。 It is on the cusp of the future generations it is where technology was 40 years ago。。 deals with the competition that drives scientists 。。I skimmed the scientific details but was absolutely fascinated by dr Doudna discoveries and the serious social consequences those discoveries have created。 Critically current to her discoveries ad the explanation of their contributions t the COVID-19 vaccines。 Wow what a story。

Mark Evans

Great bio of an amazing scientist。 Typical top-notch quality you'd expect from Walter Isaacson。 Caution: this book can make you feel like you haven't accomplished *anything* 😂 Great bio of an amazing scientist。 Typical top-notch quality you'd expect from Walter Isaacson。 Caution: this book can make you feel like you haven't accomplished *anything* 😂 。。。more

Greg

This is a great book。 The timeline goes right up to the discovery of the COVID vaccines and how the CRISPR tools led to these discoveries。 There is also ample discussion of the ethical issues associated with the current (and near future) ability to edit the human genome。

Curtis Lohr

I have read a few of Walter Isaacson’s previous books and have enjoyed them all。 I loved reading this book! It had all the trappings of a mystery book while documenting the gene race between several talented scientists。 The book was also very timely as I prepare to take the COVID vaccine in that it gave me a good understanding of the previous science that allowed the vaccine to be developed in record time。