Inflamed Mind
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- Create Date：2021-06-21 09:54:56
- Update Date：2025-09-07
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- Author：Edward Bullmore
- ISBN：1780723725
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Summary
Worldwide， depression will be the single biggest cause of disability in the next 20 years。 But treatment for it has not changed much in the last three decades。 In the world of psychiatry， time has apparently stood still。。。 until now。 In this game-changing book， University of Cambridge Professor Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain。 He explains how and why we now know that mental disorders can have their root cause in the immune system， and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycle of stress， inflammation and depression。 The Inflamed Mind goes far beyond the clinic and the lab， representing a whole new way of looking at how mind， brain and body all work together in a sometimes misguided effort to help us survive in a hostile world。 It offers insights into the story of Western medicine， how we have got it wrong as well as right in the past， and how we could start getting to grips with depression and other mental disorders much more effectively in the future。
Reviews
John
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The underlying theory is fairly convincing and interesting， although the way its presented makes it sound like its THE cause of depression rather than the serotonergic hypothesis， whereas by the end he's saying it's a mechanism for stress to induce depression via serotonin， in a subset of patients who have inflammation markers。 By bigging it up as a revolutionary idea early on， it underwhelms by the end， especially when he mentions the sparse evidence in humans。The book gets too bogged down in g The underlying theory is fairly convincing and interesting， although the way its presented makes it sound like its THE cause of depression rather than the serotonergic hypothesis， whereas by the end he's saying it's a mechanism for stress to induce depression via serotonin， in a subset of patients who have inflammation markers。 By bigging it up as a revolutionary idea early on， it underwhelms by the end， especially when he mentions the sparse evidence in humans。The book gets too bogged down in going after the Cartesian-dualism view of medicine （not wrongly） but it gets very repetitive， and seems to be his main aim rather than talking about inflammation。Would have been a stronger message if he'd pointed out how there's many different subtypes of depression， with different symptom clusters， and they may be slightly different disorders or causes， one of which is inflammation。 He hinted at this by the end chapter but his sensational claims earlier muddied the water too much。Still， the central idea that inflammation plays a role in psychiatric/neurological disorders seems fairly sound so。 。。。more
M。 Lynes
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Fascinating， highly readable account of one of the most interesting frontiers of science。 The ideas in this book will resonate with a lot of people and have currency for years to come。
Suzanne Henwood
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Rewriting what we know about depressionA must read for anyone who works in wellbeing
Rilee
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A palpable thesis on the evolutionary origins of depressive behavior and the bio mechanisms that have made depression a global epidemic。 Very grateful for this new perspective and hopeful for better treatments in the future。
Kunal Singhal
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Some very interesting ideas about link between inflamation and depression。 It was fun to learn about our immune system a bit more。However， did not enjoy the tone of writing。
TJ
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I initially thought I’d regret purchasing this because I prefer psychotherapy over psychopharmacology， but I’m so glad I did！ A must read！
Benjamin Taddesse
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⭐️⭐️⭐️⭐️ The Inflamed Mind by Professor Bullmore examines the relationship between depression and inflammation， how the inflammation directly causes the depressed state rather than other factors
Shirley Mytnowych
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This theory and approach totally makes sense to me。
Natcat
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The book's core premise is fascinating but it could have been effectively and exhaustively discussed in less than 100 pages。 I felt that about 50% of the book was wordy padding。 The book's core premise is fascinating but it could have been effectively and exhaustively discussed in less than 100 pages。 I felt that about 50% of the book was wordy padding。 。。。more
Martin Beckett
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This is a great book and should be read by those who suffer from depression or who live with someone who does and believe that the way few look at the situation is not he best solution - it is one aspect of the medical profession that has little changed in a generation and needs to move on - read this book and you might work out the direction of travel and research that the profession should follow
Justine
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A difficult book to absorb。
Melanie Sorensen
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Could various mental illnesses be due to physical issues beyond chemical imbalance？ After reading Brain on Fire， where inflammation of the brain set off psychosis， it seems obvious。 This doctor proposes we look at the inflammation response set off by the immune system and shares the current state of research on a variety of related areas。 It seems like a valid plea for researchers to explore these areas。
Eric
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The book advances a theory that inflamation caused by our immune systems contribute to or cause depression。 The case is a highly circumstantial and interesting speculation。 Perhaps future data will strengthen the thesis。 Maybe not。
Ellie Rhodes
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An incredibly interesting book that highlights how， even 3 years after the book was written， it is damaging to separate health care into the three distinctive categories of physical， mental and dental health。 There is proof that all three overlap and influence each other， regardless of sceptics questioning Bullmore's focus on inflammation。 These three professions are encouraged not to overlap during training， which leads to so many patients not being treated effectively。 Healthcare is not black An incredibly interesting book that highlights how， even 3 years after the book was written， it is damaging to separate health care into the three distinctive categories of physical， mental and dental health。 There is proof that all three overlap and influence each other， regardless of sceptics questioning Bullmore's focus on inflammation。 These three professions are encouraged not to overlap during training， which leads to so many patients not being treated effectively。 Healthcare is not black and white; as society is coming to realise， many illnesses can be measured on a spectrum and overlap with other illnesses。 Bullmore argues that it is essential to consider these overlaps in order to effectively treat patients。 。。。more
Eseink Kuo
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It’s interesting to find a new possible explanation between inflammation and mental disorder diseases。 However， after reading this book I still not sure if we can put a simple causality relationship between them。
Jonathan
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Whilst I am not a Doctor of Psychiatry， I do suffer from Depression and was keen to read this book to perhaps get some alternative ideas or concepts on Mental Illness。 This book has them in “spades” it is well worth reading if only from a historical point of view but is much much more！ New ideas in the treatment of Mental Illness are hopefully coming - perhaps this book will shake the Medical system and Pharmaceutical companies into action！
Catherine Melia
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This book has helped me start to understand the link between my inflammatory illness and my history of mental health。 Even the ‘science bits’ are written in a way that even someone like me， who’s academic abilities lie elsewhere， can understand。
Betsy
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Great info but so dry。 I struggled to get through it。 It reads more like a dissertation or long journal article， so be prepared if you start it。 But I do agree with the author- depression and inflammation are wildly intertwined and that can’t be ignored。
Alison Dawson
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I only made it half way through this one。 First， I felt like it was overly detailed about things that I already knew。 I would say this book could've been about half as long with better editing。 Two， I tuned out when I knew he was making claims that weren't really backed up， like the connection between elevated CRP levels and depression。 There may be SOME connection between depression and inflammation but I am rather leery of these physical connection theories that are often totally outlandish （l I only made it half way through this one。 First， I felt like it was overly detailed about things that I already knew。 I would say this book could've been about half as long with better editing。 Two， I tuned out when I knew he was making claims that weren't really backed up， like the connection between elevated CRP levels and depression。 There may be SOME connection between depression and inflammation but I am rather leery of these physical connection theories that are often totally outlandish （like the chemical imbalance theory that came to ridiculously be known as fact） The reality is that there are myriad reasons for depression and it's almost always not as easy as taking a pill（not to mention that pills often carry many problems）。 。。。more
Giangy Giang
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Not what i expected， the authour mostly writes about the history of immunotherapy other than explaining the science behind it。
Cara L。
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Smug， self congratulatory， and lacking in actual evidence。 There may be truth in here but it's drowned out by the back patting。 Smug， self congratulatory， and lacking in actual evidence。 There may be truth in here but it's drowned out by the back patting。 。。。more
Alicia Bayer
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This is an excellent book by a psychiatrist who has compelling reasons to suggest that for many people， inflammation in the body （and then the brain） leads to depression。 Bullmore started his career as a doctor on the medical side of things before switching to psychiatry （medical doctors who specialize in mental disorders）。 He talks about the fact that the two fields really have an Apartheid-like relationship to each other and never treat patients as a whole。 He was trained as a medical doctor t This is an excellent book by a psychiatrist who has compelling reasons to suggest that for many people， inflammation in the body （and then the brain） leads to depression。 Bullmore started his career as a doctor on the medical side of things before switching to psychiatry （medical doctors who specialize in mental disorders）。 He talks about the fact that the two fields really have an Apartheid-like relationship to each other and never treat patients as a whole。 He was trained as a medical doctor that his patients with illnesses like arthritis were very depressed just because "you would be" under the circumstances， never that the illness might actually have a physical trigger for depression。 He also writes of his time working for Glaxo Smith Kline trying to work on new antidepressants and the fact that nobody has been looking at anything but SSRI medication for 20 years， despite the fact that the main premise behind them has never actually been proven and that depression is very unlikely to only have one cause。 GSK ended up shutting down their entire antidepressant section， saying it was too expensive and most of the drugs they were trying failed。 He also gives insight into the process they use， and it's no wonder they all fail。 All of the new drugs were in the same SSRI field and they have a ridiculous model for developing them that involves first hanging mice by their tails and seeing if the drug makes them give up struggling in more or less time， and then moving on to badly designed trials in humans。The book goes deeply into the history of psychiatry， antidepressants， inflammation and the immune system。 It's fascinating for those who are science nuts but is very long。 He does an excellent job of convincing the reader that inflammation is almost certainly linked to depression in many people， and in showing you what causes inflammation and how to find out if you have it。 Where the book is less promising is in telling you how to help it。 He's a psychiatrist who worked in developing medications， and that's his sole focus。 There is almost no talk of anything other than prescription drugs for treating inflammation， though he does acknowledge that lifestyle changes make a huge difference （he says it's too hard to make those lifestyle changes when you're depressed）。 He also says that an implant that sends electrical charges to the vagus nerve has shown very good results in treating depression in people。 That has been approved as a treatment for years but it's expensive and invasive， and nobody knows why it works。 He ends the book with a sort of hopeful plea for doctors and pharma companies to quickly get on board so we can help people。I really wish he had talked about the many ways that you can decrease inflammation -- supplements like garlic， turmeric and ginger; mindfulness training and meditation; movement and exercise; and so on。 I also just read a book by another medical doctor about the effects that grounding have on inflammation and I looked up studies after reading that book and that's a really fascinating method that has shown remarkable effects on inflammation and wound healing （here's one fascinating study published in the Journal of Inflammation Research that also has images of the dramatic effects on three patients: https://www。dovepress。com/the-effects。。。）。 Bullmore is single minded in his focus on pharmaceutical interventions though。 The book is well supported with a full 1/4 of the pages devoted to references。 It's a great read for anyone interested in learning more about depression， inflammation， and the history of the two。I read a digital ARC of this book for review。 。。。more
Heather Harris
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Fascinating。 And a topic that resonates personally。 Edward Bullmore examines a different view of depression， linking it in many cases to inflammation。 What comes 1st？ Inflammation？ Or depression？ Can chronic inflammatory conditions really cause depression？ There is plenty of evidence to say yes。 And discussion that in many cases， treat the inflammation， and the depression improves。 Of course， it is more complex than that， but this could open up avenues of treatment for a large subgroup of patien Fascinating。 And a topic that resonates personally。 Edward Bullmore examines a different view of depression， linking it in many cases to inflammation。 What comes 1st？ Inflammation？ Or depression？ Can chronic inflammatory conditions really cause depression？ There is plenty of evidence to say yes。 And discussion that in many cases， treat the inflammation， and the depression improves。 Of course， it is more complex than that， but this could open up avenues of treatment for a large subgroup of patients who suffer from depression and anxiety。 Thought provoking and accessible to the general population。 。。。more
Allie Kaelin
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mrs ppppppppppppp
MediSN
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Dr。 Bullmore's new approach to depression is advertised as "radical"- yet it is only radical in some ways， and a long time coming in others。 It is radical in the sense that neither depression， nor any other mental health illness， has ever been proposed to be treatable with anti-inflammatory medication。 The research that implicates systemic inflammation as a causal factor in these diseases is definitely promising enough to be explored in clinical trials， as Dr。 Bullmore suggests。 I found the phar Dr。 Bullmore's new approach to depression is advertised as "radical"- yet it is only radical in some ways， and a long time coming in others。 It is radical in the sense that neither depression， nor any other mental health illness， has ever been proposed to be treatable with anti-inflammatory medication。 The research that implicates systemic inflammation as a causal factor in these diseases is definitely promising enough to be explored in clinical trials， as Dr。 Bullmore suggests。 I found the pharmacological aspect of this groundbreaking， and in this sense， Dr。 Bullmore's book is an essential read for all current and future pracitioners of psychiatry and mental health。 The current expensive and time consuming method of seeking out the next "blockbuster drug" is prone to failure; thus， focusing on inexpensive medication that already exists is a very new and interesting place to steer antidepressent research。 While the scientific aspect of this was definitely novel， I found certain concepts of his narrative actually quite dated。 For one， all multifactorial diseases are moving towards an individualized approach in their treatment。 He mentions this himself， while refering to the treatment of cardiovascular disease and cancer。 Thus， I understand his reluctance to focus too much on this in the book， as it goes against his claims of "a radical new approach"。 He only really emphasizes in the last chapter that this approach would only work for a subset of "inflamed depression" patients， assuming that this subset exists。 The lack of this explanation felt like a huge plot hole to me， and had me questioning the impact of inflammatory research in depression for the majority of the book。 Overall， while I am not entirely convinced that inflammation plays a distinct causal role in the development of depression， I am able to look past that， when accepting that Dr。 Bullmore was not trying to convince anyone of this。 He is simply putting forth the research that exists， and establishing the importance of further pharmacological research in this direction。 If he is right， then in 5-10 years， a subset of mental health patients will be treated for an incredibly debilitating disease that was once thought incurable。 For this reason alone， this book is an important read， and I would recommend this to all medical students and practitioners。 。。。more
Elizabeth S
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Though the thesis and supporting information are fascinating， I struggled to get through this book。 So much so that at 65% of the way through， I finally gave up。 I really appreciate what the author is saying and the detail he provides is incredible — but it is also overwhelming。 I got lost many times and often wished for a cliffs notes version or an article that spoke a little more plainly。 This is a fantastic book for someone with a bit more formal training in the human body， medicine， and/or p Though the thesis and supporting information are fascinating， I struggled to get through this book。 So much so that at 65% of the way through， I finally gave up。 I really appreciate what the author is saying and the detail he provides is incredible — but it is also overwhelming。 I got lost many times and often wished for a cliffs notes version or an article that spoke a little more plainly。 This is a fantastic book for someone with a bit more formal training in the human body， medicine， and/or psychiatry than I have。 Or perhaps it is fine for a layperson too， but with a bit more patience than I have。 。。。more
Rosalind
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Excellently written and highly informative book on the topic of inflammation and depression。
Lara Panfilov
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I was excited to read this book and to find out more about this “radical new approach” to depression。 I completely agree with Bullomore that depression is a major issue and that the progress in the last decades made in this field has stalled。 However， I believe that Bullomore book is filled with unsubstantial claims and that nothing new or innovative is mentioned that can be confirmed by solid scientific evidence。 I am keeping an open mind about the inflamed brain hypothesis， and maybe it can be I was excited to read this book and to find out more about this “radical new approach” to depression。 I completely agree with Bullomore that depression is a major issue and that the progress in the last decades made in this field has stalled。 However， I believe that Bullomore book is filled with unsubstantial claims and that nothing new or innovative is mentioned that can be confirmed by solid scientific evidence。 I am keeping an open mind about the inflamed brain hypothesis， and maybe it can be of some use to certain people， but I don’t think Bullomore’s accusations of current psychiatrists are valid if immune-psychiatry has very little evidence。 Overall I expected more and consider the end result quite disappointing。 。。。more
Silvia Rodriguez
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Interesting but a bit disappointing: too much about the business of finding the next blockbuster on depressive medication and make it commercially viable。 I liked the new perspective of inflamed body as one of the causes of depression， and I found the Darwin’s evolution side very intriguing。
Pat Jennings
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Enlightening information about how pervasive inflammation is in both the body and the mind。
Reference
google book https://www.google.com/search?tbm=bks&q=Inflamed Mind
hathitrust digital library https://babel.hathitrust.org/cgi/ls?q1=Inflamed Mind&field1=ocr&a=srchls&ft=ft&lmt=ft
The British Library https://bll01.primo.exlibrisgroup.com/discovery/search?query=any,contains,Inflamed Mind&tab=LibraryCatalog&search_scope=Not_BL_Suppress&vid=44BL_INST:BLL01&lang=en&offset=0