In a city so dismal it's known only as "the Hole，" a clan of Sorcerers has been plucking people off the streets to use as guinea pigs for atrocious "experiments" in the black arts。 In a dark alley， Nikaido found Caiman， a man with a reptile head and a bad case of amnesia。 To undo the spell， they're hunting and killing the Sorcerers in the Hole， hoping that eventually they'll kill the right one。 But when En， the head Sorcerer， gets word of a lizard-man slaughtering his people， he sends a crew of "cleaners" into the Hole， igniting a war between two worlds。

Inside the pool of waste， evil begins to brew。 The En Family leaves the hospital in search of a new hideout。 They head for the Middle Department store， which has turned into a dark， warped skyscraper for the once-a-year Living Dead Day。 When Ebisu and Kikurage are separated from the group， the rest of En Family searches for them inside the store。