A Molecule Away from Madness: Tales of the Hijacked Brain

A Molecule Away from Madness: Tales of the Hijacked Brain

  • Downloads:6970
  • Type:Epub+TxT+PDF+Mobi
  • Create Date:2022-02-27 03:19:42
  • Update Date:2025-09-06
  • Status:finish
  • Author:Sara Manning Peskin
  • ISBN:1324002379
  • Environment:PC/Android/iPhone/iPad/Kindle

Summary

Our brains are the most complex machines known to humankind, but they have an Achilles heel: the very molecules that allow us to exist can also sabotage our minds。 Here are gripping accounts of unruly molecules and the diseases that form in their wake。

A college student cannot remember if she has eaten breakfast。 By dinner, she is strapped to a hospital bed, convinced she is battling zombies。 A man planning to propose marriage instead becomes violently enraged, gripped by body spasms so severe that he nearly bites off his own tongue。 One after another, poor farmers in South Carolina drop dead from a mysterious epidemic of dementia。

With an intoxicating blend of history and intrigue, Sara Manning Peskin invites readers to play medical detective, tracing each diagnosis from the patient to an ailing nervous system。 Along the way, Peskin entertains with tales of the sometimes outlandish, often criticized, and forever devoted scientists who discovered it all。

Peskin never loses sight of the human impact of these conditions。 Alzheimer’s Disease is more than the gradual loss of a loved one; it can be a family’s multigenerational curse。 The proteins that abound in every cell of our bodies are not simply strings of oxygen, hydrogen, nitrogen, and carbon; they are the building blocks of our personalities and relationships。 A Molecule Away from Madness is an unputdownable journey into the deepest mysteries of our brains。

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Reviews

Aunfa Ugact

Had a great journey learning about the brain, drugs, bio-structure, and medical systems。

Hunter Blackthorne

Dementia is the biological proof that humans are not evolved to live as long as we do。 In light of our biotechnical achievement, kind people like Dr。 Peskin are needed to wade through memories like flotsam in the crushing tides of alzheimer's, with nothing but the hope and dedication of finding salvation。 Dementia is the biological proof that humans are not evolved to live as long as we do。 In light of our biotechnical achievement, kind people like Dr。 Peskin are needed to wade through memories like flotsam in the crushing tides of alzheimer's, with nothing but the hope and dedication of finding salvation。 。。。more

Jennifer

Fascinating ReadA wonderful book that is both interesting and easy to understand for those who do not have a science/medical background。 Extremely insightful and educational。

Petra X trying to enjoy the good for what it was

The most joyous speciality in medicine has to be obstetrics。 Not patients, but women who have come in for medical care for just a few hours and don't need healing, but helping to bring new life into the world and to leave a few hours or days later with a bundle of joy all wrapped up in love。 Conversely, the author has, to me, just about the most depressing speciality。 She is an Alzheimer's doctor:"I became a dementia doctor, at once horrified and and fascinated by the way Alzheimer's disease and The most joyous speciality in medicine has to be obstetrics。 Not patients, but women who have come in for medical care for just a few hours and don't need healing, but helping to bring new life into the world and to leave a few hours or days later with a bundle of joy all wrapped up in love。 Conversely, the author has, to me, just about the most depressing speciality。 She is an Alzheimer's doctor:"I became a dementia doctor, at once horrified and and fascinated by the way Alzheimer's disease and other types of dementia can change a person's personality。 Today, I spend most days watching my patients slowly disappear as their husbands, wives, children and sometimes parents look on in anguish。""I am, in many ways, a guide on the path to nothingness。" Great writing! I hope the book lives up to it。 。。。more

Leah

Captivating in the most nerve-wracking way possible, A Molecule Away from Madness leads the reader on a journey showcasing the havoc that the tiniest culprits can wreak on the biology that most fundamentally makes us who we are。 Covering diseases that remain terrifyingly deadly today like Creutzfeldt-Jakob Syndrome to vitamin deficiencies we've since identified and learned how to treat, every chapter brings new revelations of the power of a single molecule told in personal anecdotes that truly d Captivating in the most nerve-wracking way possible, A Molecule Away from Madness leads the reader on a journey showcasing the havoc that the tiniest culprits can wreak on the biology that most fundamentally makes us who we are。 Covering diseases that remain terrifyingly deadly today like Creutzfeldt-Jakob Syndrome to vitamin deficiencies we've since identified and learned how to treat, every chapter brings new revelations of the power of a single molecule told in personal anecdotes that truly drive home the reality of these microscopic threats。Dr。 Peskin starts out with DNA mutations - in fact, the largest of all molecules she will cover in this book。 The first story she covers is one of a woman who has complete control over her body's finest movements as an aerialist and expert practitioner of parkour, but when genetic testing reveals that she will succumb to the same Huntington's-riddled fate as her mother, she knows her fate is indelibly sealed。 But what is most interesting about this chapter is the underlying science used to isolate the gene sequence responsible for Huntington's, finally succeeding in 1993, still several years before the entire genome was mapped。 But even once that was identified, it became clear that this malformation was only the proximal cause of disease; it was the protein synthesis that the gene directed the body to undertake that resulted in the symptoms of disease。 Only armed with this understanding was an effective treatment developed for this devastating disease in 2018。 The next chapter gets into Alzheimer's with a compelling snapshot of a subset of the disease known in Colombia as la bobera。 In this case, genetic sequencing was able to show that those who were afflicted by this early-onset form of the disease suffered from a mutation that incorrectly designs proteins that break up molecules in a manner that results in a toxic buildup of plaque in the organs。 Once this was discovered, research into treatment was still stymied by violence and a heaping dose of prejudice and stereotype about the influence of the drug economy in Colombia。 A few years later, on-site research was finally underway, with results set to release later this year。 The fascinating lesson here is the value that came from the study of this one small subset of disease: "that the cure for the common case of Alzheimer's disease will be found not in the general population but rather on the molecular fringe。"Part two is a wild ride of protein-induced hysteria, from those mimic the effects of PCP and make people think they are surrounded by zombies to those that bind to the same receptors of strychnine, a poison used by a serial killer in the 1880s to induce particularly cruel deaths in women。 Here we learn that PCP was originally marketed as an anesthetic in the 1960s before its incredibly dangerous hallucinogenic effects were fully understood。 The idea that our immune systems can, with only the best intention, produce massive quantities of proteins that act in the same manner as PCP or strychnine makes for one wild and surreal ride as we hear the stories of a young college girl who believes she is living in the world of The Walking Dead to a man who believes a spider outside his car window was his once soon-to-be wife and that he himself was President of the United States。 Of course no discussion of errant proteins would be complete without a tale of prions and Creutzfeldt-Jakob Syndrome。 Focusing on the related spongiform encephalopathy of kuru in Papua New Guinea, Dr。 Peskin shows us the importance of anthropology in solving some of medicine's toughest mysteries as well。 Without someone who could take the time to understand the cultural practices of the Fore people, this disease would have continued to ravage their people for generations to come。 Equally fascinating in this chapter is the work it took to convince the medical community that proteins on their own could be infectious and the way that they unfold can distort the shape of those around them despite not being able to replicate on their own。 While there is still no treatment for Creutzfeldt-Jakob Syndrome, this chapter does highlight some promising research as well。The final part focuses on small molecules, those orders of magnitude smaller than the ones discussed elsewhere in this book。 From mercury poisoning to vitamin deficiencies, these small surpluses and deficiencies in our biochemistry can have far-reaching effects。 The experiments described in this part are absolutely off-the-charts unethical, and throw a spotlight on the absurd lengths to which scientists have sometimes had to go to validate even their clearest results when they contradict conventional wisdom。 The exploitation of prisoners and children in orphanages and people institutionalized in asylums in this section gave me a whole new appreciation for the headaches of Institutional Review Boards。 Whether you come to this book intrigued by anecdotes of madness, mentions of zombies and cannibalism and serial killers, or the marvels of science, you are sure to not be disappointed。 It is a quick, engrossing, and clear read that puts the smallest components of our body into new perspective。 Highly recommend, and very grateful to W。W。 Norton and NetGalley for the eARC in exchange for the review。 。。。more

Jason Frasca

Well done! Quite an interesting read from neurology perspective。 Even with my health care background, I learned a lot about mental health and the biology behind it。 My only issue is at times, there are tangents that seem unrelated。 For readers interested, please keep reading because eventually they make sense。 I promise。 It is well done and I highly recommend。

Elie Lehmann

Fascinating book that sits at the intersection of readable science, riveting history, and challenging, yet deeply touching family dynamics。 This book is incredibly well researched and brings the reader on a journey across at least 4 continents, several centuries and billions of neurons。 As a non-scientist, Peskin's writing taught me a ton about DNA, genetics, and how our brains work。 Definitely recommend this book。 Fascinating book that sits at the intersection of readable science, riveting history, and challenging, yet deeply touching family dynamics。 This book is incredibly well researched and brings the reader on a journey across at least 4 continents, several centuries and billions of neurons。 As a non-scientist, Peskin's writing taught me a ton about DNA, genetics, and how our brains work。 Definitely recommend this book。 。。。more

Lissa00

This book is equal parts fascinating and terrifying。 The author is a cognitive neurologist with stories of patients that have rare neurological disorders。 Typically one small thing is off in their brain and it sends them in a direction of horrible illness and even death。 This is a really well written book and it includes a good mix of scientific information and real life anecdotes。 I received a digital ARC of this book through NetGalley in exchange for an honest review。

Joseph Bale

A fascinating journey into neurology, science and medicine through gripping stories and incredible history。 It begins with an overview of the brain, how it develops and the types of threats that it's susceptible to。 The author is great at explaining the science in ways that I could understand。 She then proceeds to illustrate the different types of threats through stories and history。 The stories are harrowing。 They take the reader from jungle-dwelling cannibals in the Pacific to lost communities A fascinating journey into neurology, science and medicine through gripping stories and incredible history。 It begins with an overview of the brain, how it develops and the types of threats that it's susceptible to。 The author is great at explaining the science in ways that I could understand。 She then proceeds to illustrate the different types of threats through stories and history。 The stories are harrowing。 They take the reader from jungle-dwelling cannibals in the Pacific to lost communities in Colombia terrorized by violence to an unsuspecting student in the US who suddenly finds herself surrounded by zombies in The Walking Dead!I love books that introduce me to a new discipline through compelling stories and this was exactly that。 Without any background in medicine or science, I now feel like I have a basic understanding of neurology, the brain and the challenges doctors, patients and researches face protecting it。 。。。more

Allyson Dyar

As I read A Molecule Away from Madness, it reminded me of my favorite medical narrative writer, Berton Roueché。 In fact, it was his book “The Incurable Wound” that I had purchased at my elementary school’s book fair that awakened my interest in medical history。The author uses a simple formula to introduce the reader to the miscreant molecules that alter the brain chemistry and cause disease。 She uses narratives to present the patient the way that he or she was then details how the disease affect As I read A Molecule Away from Madness, it reminded me of my favorite medical narrative writer, Berton Roueché。 In fact, it was his book “The Incurable Wound” that I had purchased at my elementary school’s book fair that awakened my interest in medical history。The author uses a simple formula to introduce the reader to the miscreant molecules that alter the brain chemistry and cause disease。 She uses narratives to present the patient the way that he or she was then details how the disease affected this person。 Once the patient has a diagnosis, she delves into the history of the scientist(s) who discovered the disease in question and the cure, if any。 I was particularly interested in the history of the disease but I also found the patient narratives compelling。I highly recommend this is a book for anyone with an interest medical history and/or neurology。 。。。more

Emily Correia

This book is an incredible dive into how our DNA can impact diseases, especially as they relate to our brain。 The author does an excellent job teaching readers about the discovery of genetic mutations that can lead to diseases like Huntington’s and Alzheimer’s through a series of stories。 I found each of the stories to be just the right length to be informative enough to understand the full story while also not diving too deep to overwhelm the reader。 Each story gives enough closure to wrap up This book is an incredible dive into how our DNA can impact diseases, especially as they relate to our brain。 The author does an excellent job teaching readers about the discovery of genetic mutations that can lead to diseases like Huntington’s and Alzheimer’s through a series of stories。 I found each of the stories to be just the right length to be informative enough to understand the full story while also not diving too deep to overwhelm the reader。 Each story gives enough closure to wrap up the point nicely, but also piques your curiosity with enough details to arm you if your wanted to do a deeper dive。 One particularly interesting case follows a woman named Lauren through her “walking dead disease” where she is convinced that she is living in the TV show The Walking Dead for months。 In this anecdote the author explains that in many cases, doctors and nurses assumed she was using the drug PCP。 She then includes information about the creation and medical uses for PCP in the 60s and its evolution to a street drug。 I would highly recommend this read for anyone with a curious mind about the ways our minds can change over time。 。。。more